Description
P-21
Peptide 021 (Ac-DGGLAG-NH2, P021, GLXC-21260) is a synthetic peptide derivative that is derived from a 4-amino acid active fragment of ciliary neurotrophic factor, which has been substituted with an unnatural adamantane based amino acid residue on the end of the chain. This substitution is highly lipophilic and facilitates transport of the molecule across the blood-brain barrier. It has neurotrophic effects and enhances neurogenesis, and has been investigated for treatment of neurological disorders such as Alzheimer's disease
Laboratory Research Data Analysis
- 28-amino-acid neuropeptide
- Derived from the prepro-orexin precursor
- One of two orexin peptides: Orexin A and Orexin B
- Interacts primarily with the OX2 orexin receptor (OX2R)
- Involved in neuronal signalling and arousal pathways
- Studied in neuroscience and neurobiology research
- Investigated in relation to energy-balance and metabolic signalling
- Cell-based assays: analysis of receptor activity and cellular signalling
- Used in research examining orexin receptor activation and downstream pathways
